It is believed that the primary difficulty in protein loop structure prediction comes from the number of residues in the loop. As loop span appears to be independent of global properties of the protein we suggest that its distribution can be described by a random fluctuation model based on the Maxwell–Boltzmann distribution. Loop span is also unaffected by the secondary structures at the end points, unless the two anchors are part of an anti- parallel beta sheet. We find that the distribution of loop span appears to be independent of the number of residues in the loop, in other words the separation between the anchors of a loop does not increase with an increase in the number of loop residues. Here we examine the distance between a loop’s end points (span). In particular protein loop classifications and database search methods depend heavily on local properties of loops. Most protein loop structure prediction methods sample local loop segments and score them. 3.1 Introduction 45 3.2 Protein and Gene Family. Database Annotation in Molecular Biology. Database Annotation in Molecular Biology EDITOR. Introduction to Protein Architecture, Oxford: Oxford. Despite their importance, their structure remains difficult to predict. How long is a piece of loop? They often play important roles in function, including enzyme reactions and ligand binding. Introduction To Protein Science Lesk Pdf To Jpg Rating: 7,9/10 1624 reviews
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